Evaluating Colloidal Silver and Toxicity :
This document contains the
original text of the EPA's study of silver consumption which documents the
relationship between the amount of silver ingested and the risk of argyria, as
well as fully documenting all pertinent toxilogical information concerning the
use of silver in the human body.
As the EPA studies show, the estimated
amount of silver intake in order to be at risk for Argyria is 3.8 ( to six )
grams of silver.
One teaspoon of 5 ppm colloidal silver
contains about 25 micrograms of silver, or .025 milligrams of silver. Six
teaspoons, the equivalent of one fluid ounce, therefore contains .15 milligrams
of silver. The EPA's critical dose for a 160 lb. adult is 1.09 milligrams daily.
Taking one ounce of colloidal silver daily, according to EPA guidelines, is well
below the critical daily intake for the development of argyria. Four ounces
daily would equal around .6 milligrams.
However, all of this is dependent upon
the body's actual retention of colloidal silver in body tissues. There is no
existing data which addresses the very real differences between isolated ionic
silver ( and particles sized .0003 - .05 microns in diameter), and silver
compounds ( silver nitrate, silver arsphenamine , silver proteins, silver salts,
silver acetate, etc. ). Can a risk assessment for argyria based on high strength
ionic silver compounds be applied to low PPM isolated silver solutions and
colloidal silver? This is unknown.
There is accumulating evidence which
strongly suggests that neither low PPM isolated ionic silver nor minutely sized
silver particles build up in the body at the same rate indicated by the compound
study data. Many researchers have traditionally been unable to explain the exact
risk elements associated with silver toxicity-- why one individual is at risk
for argyria and why another is no, when the amount of silver ingested is the
same. As some of the research data shows, however, a selenium deficiency may be
a determining factor.
If selenium and other dietary factors
are the sole determining factor in the risks associated with argyria ( aside
from obvious massive overdoses ), then dose quantities, frequency of use, and
actual silver concentration become of paramount importance in gauging risk. If
dietary intake and systemic availability of needed substances exceed those
required as a part of silver elimination in the body, then the accumulation of
silver in the body will not be comparable to the high potency compound products,
and thus the risk of argyria will not be equal.
Evidence presented in one study case
conducted by Roger Altman lends credence to the idea that silver accumulation
via oral use of an isolated colloidal silver product does not always occur.
Needless to say, though, much further work needs to be done on the subject for
Some researchers believe that build up
of silver in the body is caused exclusively by the concentration of silver
ingested, irrespective of the actual form of silver. Therefore, it would not
likely matter whether one took a silver protein that contained one milligram of
silver or one milligram of silver nitrate - the risk for argyria, whatever that
may or may not be, would be the same.
However, we do not believe this to be
the case. We do not believe that the body itself responds the same to silver
compounds as it does to isolated silver. Data inferred from the above studies
indicate a wide variance in the amount of silver deposited in those whom have
never taken a colloidal silver product. It is extremely unlikely that ANY of the
people studied ( outside of silver-rich industrial conditions ) would have
ingested large amounts of silver at any given time, and yet the variance in
accumulation in body tissues infers that there are other factors involved in
While it is our
conclusion after four years of study that the risk of Argyria from the use of a
quality isolated colloidal silver product is negligible, prudence suggests that
actual silver intake be kept below 1.09 milligrams daily until scientific
evidence demonstrates otherwise. In the event that greater doses are required
for long term treatments, dietary measures to augment the body's elimination
system are likely a good idea, including Selenium and Vitamin E supplementation
and proper hydration of the body. Measurement of silver accumulation in the body
every six months would also be a prudent and revealing measure. Considering the
actual silver content per dose, the development of argyria would only occur over
a long period of time with unnecessarily large amounts of colloidal silver used
daily. Even the most conservative estimates would put the time frame in excess
of three years.
Cure for Argyria